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Translational Approach for Predicting Human Pharmacokinetics of Engineered Therapeutic Monoclonal Antibodies with Increased FcRn-Binding Mutations

Haraya, K; Tachibana, T

Haraya, K (通讯作者),Chugai Pharmaceut Co Ltd, 1-135 Komakado, Gotemba, Shizuoka 4128513, Japan.

BIODRUGS, 2023; 37 (1): 99

Abstract

IntroductionRecently, increasing FcRn binding by Fc engineering has become a promising approach for prolonging the half-life of therapeutic monoclonal......

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