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Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA(4) Hydrolase

Hiesinger, K; Schott, A; Kramer, JS; Blospacher, R; Witt, F; Wittmann, SK; Steinhilber, D; Pogoryelov, D; Gerstmeier, J; Werz, O; Proschak, E

Proschak, E (corresponding author), Goethe Univ Frankfurt, Inst Pharmaceut Chem, Max von Laue Str 9, D-60438 Frankfurt, Germany.

ACS MEDICINAL CHEMISTRY LETTERS, 2020; 11 (3): 298

Abstract

Multitarget anti-inflammatory drugs interfering with the arachidonic acid cascade exhibit superior efficacy. In this study, a prototype dual inhibitor......

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