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Mechanism and restoration strategy of lysosomal abnormalities induced by urinary protein overload in proximal tubule epithelial cells

Li, XY; Zou, T; Wang, SJ; Wu, HL; Wu, M; Liu, ZJ; Liu, HF

Liu, HF (corresponding author), Guangdong Med Univ, Affiliated Hosp, Inst Nephrol, Zhanjiang 524001, Guangdong, Peoples R China.; Liu, HF (corresponding author), Guangdong Med Univ, Affiliated Hosp, Key Lab Prevent & Management Chron Kidney Dis Zha, Zhanjiang 524001, Guangdong, Peoples R China.

DEVELOPMENTAL DYNAMICS, ; ():

Abstract

Background: Persistent elevated concentrations of urinary protein can destroy proximal tubule epithelial cells (PTECs) by inducing lysosomal abnormali......

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