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Transdermal delivery of nobiletin using ionic liquids

Hattori, T; Tagawa, H; Inai, M; Kan, T; Kimura, S; Itai, S; Mitragotri, S; Iwao, Y

Iwao, Y (reprint author), Univ Shizuoka, Lab Pharmaceut Engn & Drug Delivery Sci, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.

SCIENTIFIC REPORTS, 2019; 9 ():

Abstract

Nobiletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however, despite these problems, various physiological ......

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