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Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1

Yang, YY; Xiang, K; Sun, DJ; Zheng, MZ; Song, ZR; Li, MX; Wang, XB; Li, H; Chen, LX

Li, H; Chen, LX (corresponding author), Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.; Wang, XB (corresponding author), Hubei Univ Med, Renmin Hosp, Oncol Ctr, Lab Chinese Herbal Pharmacol,Biomed Res Inst,Hube, Shiyan 442000, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 36 ():

Abstract

Isocitrate dehydrogenase (IDH) is one key rate-limiting enzyme in the tricarboxylic acid cycle, which is related to various cancers. Tomatillo (Physal......

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