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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

Goncharov, T; Hedayati, S; Mulvihill, MM; Izrael-Tomasevic, A; Zobel, K; Jeet, S; Fedorova, AV; Eidenschenk, C; deVoss, J; Yu, KB; Shaw, AS; Kirkpatrick, DS; Fairbrother, WJ; Deshayes, K; Vucic, D

Vucic, D (reprint author), Genentech Inc, Dept Early Discovery Biochem, 1 DNA Way, San Francisco, CA 94080 USA.

MOLECULAR CELL, 2018; 69 (4): 551

Abstract

Inflammatory responses mediated by NOD2 rely on RIP2 kinase and ubiquitin ligase XIAP for the activation of nuclear factor kappa B (NF-kappa B), mitog......

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