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Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

Dalton, G; An, SW; Al-Juboori, SI; Nischan, N; Yoon, J; Dobrinskikh, E; Hilgemann, DW; Xie, J; Luby-Phelps, K; Kohler, JJ; Birnbaumer, L; Huang, CL

Huang, CL (reprint author), Univ Texas Southwestern Med Ctr Dallas, Dept Med, Dallas, TX 75390 USA.; Birnbaumer, L (reprint author), NIEHS, Neurobiol Lab, POB 12233, Res Triangle Pk, NC 27709 USA.; Birnbaumer, L (reprint author), Catholic Univ Argentina,

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017; 114 (4): 752

Abstract

Soluble klotho, the shed ectodomain of the antiaging membrane protein a-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors an......

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