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6mer seed toxicity in tumor suppressive microRNAs

Gao, QQ; Putzbach, WE; Murmann, AE; Chen, SQ; Sarshad, AA; Peter, JM; Bartom, ET; Hafner, M; Peter, ME

Peter, ME (reprint author), Northwestern Univ, Dept Med, Div Hematol Oncol, Chicago, IL 60611 USA.; Peter, ME (reprint author), Northwestern Univ, Dept Biochem & Mol Genet, Chicago, IL 60611 USA.

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2-7 of the guide strand). Here we performed an siRNA......

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