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Intermedin(1-53) Inhibits NLRP3 Inflammasome Activation by Targeting IRE1 alpha in Cardiac Fibrosis

Zhang, LS; Zhang, JS; Hou, YL; Lu, WW; Ni, XQ; Lin, F; Liu, XY; Wang, XJ; Yu, YR; Jia, MZ; Tang, CS; Han, L; Chai, SB; Qi, YF

Qi, YF (通讯作者)，Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Hlth Sci Ctr, Beijing, Peoples R China.;Han, L (通讯作者)，Capital Med Univ, Fu Xing Hosp, Dept Cardiol, A20 Fuxingmenwai St, Beijing 100038, Peoples R China.;Chai, SB (通讯作者)，Peking Univ Int Hosp, Dept Endocrinol, Life Pk Rd 1,Zhongguancun Life Sci Pk, Beijing 102206, Peoples R China.

INFLAMMATION, 2022; 45 (4): 1568

Abstract

Intermedin (IMD), a paracrine/autocrine peptide, protects against cardiac fibrosis. However, the underlying mechanism remains poorly understood. Previ......

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