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Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)

Ahmad, S; St Hilaire, VR; Dandepally, SR; Johnson, GL; Williams, AL; Scott, JE

Scott, JE (reprint author), North Carolina Cent Univ, BRITE Bldg,Room 1019,1801 Fayetteville St, Durham, NC 27707 USA.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018; 496 (1): 205

Abstract

The kinase MEKK2 (MAP3K2) activates the MEK5/ERK5 cell signaling pathway and may play an important role in tumor growth and metastasis. Thus, MEKK2 ma......

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