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Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

Di Paolo, ML; Cervelli, M; Mariottini, P; Leonetti, A; Polticelli, F; Rosini, M; Milelli, A; Basagni, F; Venerando, R; Agostinelli, E; Minarini, A

Di Paolo, ML (reprint author), Univ Padua, Dept Mol Med, Via G Colombo 3, I-35131 Padua, Italy.; Minarini, A (reprint author), Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, Via Belmeloro 6, I-40126 Bologna, Italy.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019; 34 (1): 740

Abstract

Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1-9) or methoctramine (10-14) analogues, were evaluated as potential inhib......

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