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Significantly different effects of tetrahydroberberrubine enantiomers on dopamine D1/D2 receptors revealed by experimental study and integrated in silico simulation

Ge, HX; Bian, YM; He, XB; Xie, XQ; Wang, JM

Ge, HX (reprint author), Huzhou Univ, Sch Life Sci, Huzhou 313000, Peoples R China.; Xie, XQ; Wang, JM (reprint author), Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA.; Xie, XQ; Wang, JM (reprint author), Univ Pittsburgh, Sch P

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019; 33 (4): 447

Abstract

Tetrahydroberberrubine (TU), an active tetrahydroprotoberberines (THPBs), is gaining increasing popularity as a potential candidate for treatment of a......

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