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Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells

Rouhani, FJ; Zou, XQ; Danecek, P; Amarante, TD; Koh, G; Wu, QX; Memari, Y; Durbin, R; Martincorena, I; Bassett, AR; Gaffney, D; Nik-Zainal, S

Nik-Zainal, S (通讯作者)，Hutchison MRC Res Ctr, Early Canc Inst, Cambridge Biomed Res Campus, Cambridge, England.;Nik-Zainal, S (通讯作者)，Addenbrookes Treatment Ctr, Acad Dept Med Genet, Cambridge Biomed Res Campus, Cambridge, England.

NATURE GENETICS, 2022; 54 (9):

Abstract

We explored human induced pluripotent stem cells (hiPSCs) derived from different tissues to gain insights into genomic integrity at single-nucleotide ......

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