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Discovery of novel IDO1 inhibitors via structure-based virtual screening and biological assays

Ge, HZ; Mao, LF; Zhao, J; Wang, YW; Shi, DF; Yang, X; Wang, XR; Liu, HX; Yao, XJ

Yao, XJ (corresponding author), Lanzhou Univ, Sch Chem & Chem Engn, Lanzhou 730000, Peoples R China.; Yao, XJ (corresponding author), Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau Inst Appl Res Med & Hlth, Taipa, Macau, Peoples R China.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2021; 35 (5): 679

Abstract

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the first and rate-limiting step in catabolism of tryptophan via the k......

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