SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses-MedSci.cn

SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses

Christofides, A; Katopodi, XL; Cao, CR; Karagkouni, D; Aliazis, K; Yenyuwadee, S; Aksoylar, HI; Pal, R; Mahmoud, MAA; Strauss, L; Tijaro-Ovalle, NM; Boon, L; Asara, J; Vlachos, IS; Patsoukis, N; Boussiotis, VA

Boussiotis, VA (通讯作者)，Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02215 USA.;Boussiotis, VA (通讯作者)，Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA.;Boussiotis, VA (通讯作者)，Beth Israel Deaconess Med Ctr, Canc Ctr, Boston, MA 02215 USA.

Abstract

The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 ......

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SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses

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