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Mild and selective hydrogen-deuterium exchange for aromatic hydrogen of amines

Tachrim, ZP; Hashinoki, M; Wang, ZP; Wen, Z; Zihan, Z; Hashimoto, M

Tachrim, ZP (通讯作者),Natl Res & Innovat Agcy, Kawasan Sains Teknol KST BJ Habibie, Res Ctr Pharmaceut Ingredient & Tradit Med, S Tangerang 15314, Banten, Indonesia.;Hashimoto, M (通讯作者),Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Kita 9, Nishi 9,Kita Ku, Sapporo 0608589, Japan.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (10): 321

Abstract

The direct electrophilic deuteration of the aromatic moiety in aromatic and aralkyl amines is reported. The acid-catalyzed deuteration is facilitated ......

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