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Inhibition of tumor invasion and metastasis by targeting TGF-beta-Smad-MMP2 pathway with Asiatic acid and Naringenin

Lian, GY; Wang, QM; Mak, TSK; Huang, XR; Yu, XQ; Lan, HY

Yu, XQ (corresponding author), Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Hong Kong Joint Res Lab Immunol & Genet, Guangzhou, Peoples R China.; Yu, XQ (corresponding author), Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pathol, Guangzhou, Peoples R China.; Lan, HY (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.; Lan, HY (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R

MOLECULAR THERAPY-ONCOLYTICS, 2021; 20 (): 277

Abstract

Transforming growth factor beta (TGF-beta) has been shown to promote tumor invasion and metastasis by activating the matrix metalloproteinases (MMPs);......

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