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Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

Seabra, CM; Aneichyk, T; Erdin, S; Tai, DJC; De Esch, CEF; Razaz, P; An, Y; Manavalan, P; Ragavendran, A; Stortchevoi, A; Abad, C; Young, JI; Maciel, P; Talkowski, ME; Gusella, JF

Gusella, JF (corresponding author), Massachusetts Gen Hosp, Mol Neurogenet Unit, Ctr Genom Med, Boston, MA 02114 USA.; Gusella, JF (corresponding author), Broad Inst MIT & Harvard, Sch Med, Program Med & Populat Genet, Boston, MA 02142 USA.; Gusella, JF (corresponding author), Harvard Med Sch, Blavatn Inst, Dept Genet, Boston, MA 02115 USA.; Gusella, JF (corresponding author), Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA.

MOLECULAR AUTISM, 2020; 11 (1):

Abstract

Background MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion ......

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