SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology-MedSci.cn

SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology

Lee, AK; Yi, NY; Khaled, H; Feller, B; Takahashi, H

Takahashi, H (通讯作者)，Inst Rech Clin Montreal, Synapse Dev & Plast Res Unit, Montreal, PQ, Canada.;Takahashi, H (通讯作者)，McGill Univ, Integrated Program Neurosci, Montreal, PQ, Canada.;Takahashi, H (通讯作者)，Univ Montreal, Dept Med, Montreal, PQ, Canada.;Takahashi, H (通讯作者)，McGill Univ, Div Expt Med, Montreal, PQ, Canada.

Abstract

Amyloid-beta oligomers (A beta Os), toxic peptide aggregates found in Alzheimer's disease, cause synapse pathology. A beta Os interact with neurexins ......

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SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology

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