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Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity

Lu, GH; Miao, XS; Liu, D

Lu, GH (corresponding author), Bristol Myers Squibb, Quantitat Syst Pharmacol & Physiologically Based, Clin Pharmacol & Pharmacometr, Res & Early Dev, Princeton, NJ 08540 USA.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (9): 1103

Abstract

Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining the ionization of a drug in the human body. The Henderson-H......

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