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Chemical-Mediated Digestion: An Alternative Realm for Middle-down Proteomics?

Srzentic, K; Zhurov, KO; Lobas, AA; Nikitin, G; Fornelli, L; Gorshkov, MV; Tsybin, YO

Tsybin, YO (reprint author), Spectroswiss, EPFL Innovat Pk, CH-1015 Lausanne, Switzerland.

JOURNAL OF PROTEOME RESEARCH, 2018; 17 (6): 2005

Abstract

Protein digestion in mass spectrometry (MS) based bottom-up proteomics targets mainly lysine and arginine residues, yielding primarily 0.6-3 kDa pepti......

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