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Inhibition of PI3 kinase isoform p110a suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase

Guo, Y; Guo, DH; Zhang, ST; Zhang, Y; He, XY; Jiang, XH; Chan, AML; Zou, L; Sun, JM; Zhao, H

Zhao, H (通讯作者)，Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Key Lab Regenerat Med, Hong Kong, Peoples R China.;Sun, JM (通讯作者)，Ningxia Med Univ, Sci & Technol Ctr, Sch Basic Med Sci, NHC Key Lab Metab Cardiovasc Dis Res, 1160 Shengli St, Yinchuan 750004, Peoples R China.;Zhao, H (通讯作者)，Chinese Univ Hong Kong Joint, Kunming Inst Zool Chinese Acad Sci, Lab Bioresources & Mol Res Common Dis, Hong Kong, Peoples R China.;Zhao, H (通讯作者)，Chinese Univ Hong Kong, Hong Kong Branch CAS Ctr Excellence An

CELL AND BIOSCIENCE, 2022; 12 (1):

Abstract

Background: In neuroblastoma, hyperactivation of the PI3K signaling pathway has been correlated with aggressive neuroblastomas, suggesting PI3Ks as pr......

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