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Therapeutic options for CTLA-4 insufficiency

Egg, D; Rump, IC; Mitsuiki, N; Rojas-Restrepo, J; Maccari, ME; Schwab, C; Gabrysch, A; Warnatz, K; Goldacker, S; Patino, V; Wolff, D; Okada, S; Hayakawa, S; Shikama, Y; Kanda, K; Imai, K; Sotomatsu, M; Kuwashima, M; Kamiya, T; Morio, T; Matsumoto, K; Mori, T; Yoshimoto, Y; Dybedal, I; Kanariou, M; Kucuk, ZY; Chapdelaine, H; Petruzelkova, L; Lorenz, HM; Sullivan, KE; Heimall, J; Moutschen, M; Litzman, J; Recher, M; Albert, MH; Hauck, F; Seneviratne, S; Schmid, JP; Kolios, A; Unglik, G; Klemann, C; Snapper, S; Giulino-Roth, L; Svaton, M; Platt, CD; Hambleton, S; Neth, O; Gosse, G; Reinsch, S; Holzinger, D; Kim, YJ; Bakhtiar, S; Atschekzei, F; Schmidt, R; Sogkas, G; Chandrakasan, S; Rae, W; Derfalvi, B; Marquart, HV; Ozen, A; Kiykim, A; Karakoc-Aydiner, E; Kralickova, P; De Bree, G; Kiritsi, D; Seidel, MG; Kobbe, R; Dantzer, J; Alsina, L; Armangue, T; Lougaris, V; Agyeman, P; Nystrom, S; Buchbinder, D; Arkwright, PD; Grimbacher, B

Grimbacher, B (通讯作者),Univ Klinikum Freiburg, Ctr Chron Immunodeficiency, Breisacher Str 115, D-79106 Freiburg, Germany.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (2): 736

Abstract

Background: Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) impair the immunomodulatory function of regulatory ......

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