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Converting polar cyclic peptides into membrane permeable molecules using N-methylation

Lee, LLH; Buckton, LK; McAlpine, SR

Buckton, LK; McAlpine, SR (reprint author), Univ New South Wales, Chem, Sydney, NSW, Australia.

PEPTIDE SCIENCE, 2018; 110 (3):

Abstract

Described are the design, synthesis, and biological evaluation of 5 N-methylated analogs that are based on a lead drug structure LB51. LB51 is a cycli......

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