An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane-MedSci.cn

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Wang, C; Li, Q; Sun, LJ; Wang, XL; Wang, H; Zhang, WP; Li, JH; Liu, Y; Lu, L; Jiang, SB

Wang, C (通讯作者)，Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, 27 Tai Ping Rd, Beijing 100850, Peoples R China.;Lu, L; Jiang, SB (通讯作者)，Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Shanghai Publ Hlth Clin Ctr, Sch Basic Med Sci,Key Lab Med Mol Virol MOE NHC CA, 131 Dong Rd, Shanghai 200032, Peoples R China.;Liu, Y (通讯作者)，Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.

Abstract

Human immunodeficiency virus type 1 (HIV-1) is characterized by high variability and drug resistance. This has necessitated the development of antivir......

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An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

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