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AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis

Zhou, YH; Zhang, JL; Li, H; Huang, TT; Wong, CC; Wu, F; Wu, M; Weng, NQ; Liu, LP; Cheng, ASL; Yu, J; Wong, N; Lo, KW; Tang, PMK; Kang, W; To, KF

Kang, W; To, KF (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, State Key Lab Translat Oncol, Dept Anat & Cellular Pathol, Hong Kong, Peoples R China.; Kang, W; To, KF (corresponding author), Chinese Univ Hong Kong, Inst Digest Dis, State Key Lab Digest Dis, Hong Kong, Peoples R China.; Kang, W; To, KF (corresponding author), Chinese Univ Hong Kong, Sir YK Pao Canc Ctr, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.

ONCOGENE, 2020; 39 (22): 4375

Abstract

Hippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogenesis. YAP1/TEAD co......

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