Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain-MedSci.cn

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain

Hua, YP; Yuan, X; Shen, YH; Wang, JX; Azeem, W; Yang, S; Gade, A; Lellahi, SM; Oyan, AM; Ke, XS; Zhang, WD; Kalland, KH

Hua, YP; Kalland, KH (通讯作者)，Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Zhang, WD (通讯作者)，Second Mil Med Univ, Sch Pharm, Dept Phytochemistry, Shanghai, Peoples R China.;Kalland, KH (通讯作者)，Haukeland Hosp, Dept Microbiol, Helse Bergen, Bergen, Norway.;Zhang, WD (通讯作者)，Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai, Peoples R China.;Kalland, KH (通讯作者)，Haukeland Hosp, Dept Immunol & Transfus Med, Bergen, Norway.

Abstract

Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323-1 and 323-2 (delavatine A stereoisomers) in a series of experiments.......

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Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain

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