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Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

Stancu, IC; Cremers, N; Vanrusselt, H; Couturier, J; Vanoosthuyse, A; Kessels, S; Lodder, C; Brone, B; Huaux, F; Octave, JN; Terwel, D; Dewachter, I

Dewachter, I (reprint author), Hasselt Univ, Biomed Res Inst, B-3500 Hasselt, Belgium.; Dewachter, I (reprint author), Catholic Univ Louvain, Inst Neurosci, Alzheimer Dementia Grp, B-1200 Brussels, Belgium.

ACTA NEUROPATHOLOGICA, 2019; 137 (4): 599

Abstract

Brains of Alzheimer's disease patients are characterized by the presence of amyloid plaques and neurofibrillary tangles, both invariably associated wi......

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