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Substrate-Based Allosteric Regulation of a Homodimeric Enzyme

Mehrabi, P; Di Pietrantonio, C; Kim, TH; Sljoka, A; Taverner, K; Ing, C; Kruglyak, N; Pomes, R; Pai, EF; Prosser, RS

Pai, EF; Prosser, RS (reprint author), Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada.; Pai, EF (reprint author), Princess Margaret Canc Ctr, Campbell Family Inst Canc Res, Toronto, ON M5G 1L7, Canada.; Prosser, RS (reprint author), Univ Toro

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019; 141 (29): 11540

Abstract

Many enzymes operate through half-of-the sites reactivity wherein a single protomer is catalytically engaged at one time. In the case of the homodimer......

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