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Generation and characterization of a high-affinity chimeric anti-OX40 antibody with potent antitumor activity

Yang, YL; Chai, XJ; Xin, WF; Wang, DX; Dai, CH; Qian, F; Yang, T

Qian, F (corresponding author), Fudan Univ, Human Phenome Inst, Shanghai Publ Hlth Clin Ctr, 2005 Songhu Rd, Shanghai 200438, Peoples R China.; Qian, F (corresponding author), Fudan Univ, Sch Life Sci, 2005 Songhu Rd, Shanghai 200438, Peoples R China.; Yang, T (corresponding author), Shanghai ChemPartner Co Ltd, Bldg 10,965 Halei Rd, Shanghai 201203, Peoples R China.

FEBS LETTERS, 2021; 595 (11): 1587

Abstract

OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. OX40 agonist-based combinations are emerging a......

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