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Reprogramming CBX8-PRC1 function with a positive allosteric modulator

Suh, JL; Bsteh, D; Hart, B; Si, YB; Weaver, TM; Pribitzer, C; Lau, R; Soni, S; Ogana, H; Rectenwald, JM; Norris, JL; Cholensky, SH; Sagum, C; Umana, JD; Li, DX; Hardy, B; Bedford, MT; Mumenthaler, SM; Lenz, HJ; Kim, YM; Wang, GG; Pearce, KH; James, LI; Kireev, DB; Musselman, CA; Frye, SV; Bell, O

Frye, SV (通讯作者),Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA.;Bell, O (通讯作者),Univ Southern Calif, Dept Biochem & Mol Med, Keck Sch Med, Los Angeles, CA 90033 USA.;Bell, O (通讯作者),Austrian Acad Sci IMBA, Vienna Bioctr VBC, Inst Mol Biotechnol, Dr Bohr Gasse 3, A-1030 Vienna, Austria.;Frye, SV (通讯作者),Univ N Carolina, UNC Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.

CELL CHEMICAL BIOLOGY, 2022; 29 (4): 555

Abstract

Canonical targeting of Polycomb repressive complex 1 (PRC1) to repress developmental genes is mediated by cell-type-specific, paralogous chromobox (CB......

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