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Discovery and antitumor activity of Benzo[d]imidazol-containing 2,4-dia-rylaminopyrimidine analogues as ALK inhibitors with mutation-combating effects

Li, Z; Guo, M; Cao, M; Zhao, TM; Li, MZ; Zhai, X

Li, MZ (corresponding author), China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Integrated Tradit Chinese & Western Med Med, Shenyang 110042, Peoples R China.; Zhai, X (corresponding author), Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 37 ():

Abstract

To address drug resistance caused by ALK kinase mutations, a series of novel 2,4-diarylaminopyrimidine (DAAP) analogues were designed by incorporating......

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