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Cancer proteome and metabolite changes linked to SHMT2

Tong, JF; Krieger, JR; Taylor, P; Bagshaw, R; Kang, J; Jeedigunta, S; Wybenga-Groot, LE; Zhang, W; Badr, H; Mirhadi, S; Pham, NA; Coyaud, E; Yu, M; Li, M; Cabanero, M; Raught, B; Maynes, JT; Hawkins, C; Tsao, MS; Moran, MF

Moran, MF (corresponding author), Hosp Sick Children, Program Cell Biol, Toronto, ON, Canada.; Moran, MF (corresponding author), Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.; Moran, MF (corresponding author), Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.

PLOS ONE, 2020; 15 (9):

Abstract

Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protei......

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