Design, synthesis and biological evaluation of 1,5-disubstituted a-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders-MedSci.cn

Design, synthesis and biological evaluation of 1,5-disubstituted a-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

Ulgheri, F; Spanu, P; Deligia, F; Loriga, G; Fuggetta, MP; de Haan, I; Chandgudge, A; Groves, M; Domling, A

Ulgheri, F; Spanu, P (通讯作者)，Natl Res Council CNR, Inst Biomol Chem, Trav La Crucca 3, I-07100 Sassari, Italy.;Domling, A (通讯作者)，Univ Groningen, Dept Drug Design, NL-9713 AV Groningen, Netherlands.

Abstract

Compounds targeting the inflammasome-caspase-1 pathway could be of use for the treatment of inflammation and inflammatory diseases. Previous caspase-1......

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Design, synthesis and biological evaluation of 1,5-disubstituted a-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

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