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Design and Synthesis of Novel, Selective GPR40 AgoPAMs

Plummer, CW; Clements, MJ; Chen, H; Rajagopalan, M; Josien, H; Hagmann, WK; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Nolting, AF; Orr, R; Christensen, M; Campeau, LC; Wright, MJ; Bugianesi, R; So

Plummer, CW (reprint author), Merck Res Labs, Dept Discovery Chem, Kenilworth, NJ 07033 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2017; 8 (2): 221

Abstract

GPR40 is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent the......

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