Direct reprogramming of mouse fibroblasts into hepatocyte-like cells by polyethyleneimine-modified nanoparticles through epigenetic activation of hepatic transcription factors-MedSci.cn

Direct reprogramming of mouse fibroblasts into hepatocyte-like cells by polyethyleneimine-modified nanoparticles through epigenetic activation of hepatic transcription factors

Wang, M; Yu, J; Cai, L; Yang, X

Wang, M (corresponding author), East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Synthet Biol & Biomed Engn Lab, Shanghai 200241, Peoples R China.; Wang, M (corresponding author), East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China.

Abstract

Direct reprogramming without an intermediate pluripotent state has great therapeutic potential in regenerative medicine. Controlling lineage-specific ......

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Direct reprogramming of mouse fibroblasts into hepatocyte-like cells by polyethyleneimine-modified nanoparticles through epigenetic activation of hepatic transcription factors

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