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Inhibition of a viral prolyl hydroxylase

Langley, GW; Abboud, MI; Lohans, CT; Schofield, CJ

Schofield, CJ (reprint author), Univ Oxford, Dept Chem, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England.

BIOORGANIC & MEDICINAL CHEMISTRY, 2019; 27 (12): 2405

Abstract

The hydroxylation of prolyl-residues in eukaryotes is important in collagen biosynthesis and in hypoxic signalling. The hypoxia inducible factor (HIF)......

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