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Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/gamma H2AX pathway

Wang, Z; Chen, Q; Li, B; Xie, JM; Yang, XD; Zhao, K; Wu, Y; Ye, ZY; Chen, ZR; Qin, ZH; Xing, CG

Xing, CG (reprint author), Soochow Univ, Affiliated Hosp 2, Dept Gen Surg, Suzhou 215007, Peoples R China.; Qin, ZH (reprint author), Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Peoples R China.; Qin, ZH (reprint author), Soochow Uni

ACTA PHARMACOLOGICA SINICA, 2018; 39 (10): 1645

Abstract

Escin, a triterpene saponin isolated from horse chestnut seed, has been used to treat encephaledema, tissue swelling and chronic venous insufficiency.......

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