Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects-MedSci.cn

Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects

Kang, P; Cho, CK; Jang, CG; Lee, SY; Lee, YJ; Choi, CI; Bae, JW

Lee, SY (通讯作者)，Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea.;Choi, CI (通讯作者)，Dongguk Univ Seoul, Coll Pharm, Goyang 10326, South Korea.;Bae, JW (通讯作者)，Keimyung Univ, Coll Pharm, Daegu 42601, South Korea.

Abstract

Gliclazide metabolism is mediated by genetically polymorphic CYP2C9 and CYP2C19 enzymes. We investigated the effects of CYP2C9 and CYP2C19 genetic pol......

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Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects

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