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Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer

Wu, YS; Yu, HJ; Li, SW; Wiley, K; Zheng, SL; LaDuca, H; Gielzak, M; Na, R; Sarver, BAJ; Helfand, BT; Walsh, PC; Lotan, TL; Cooney, KA; Black, MH; Xu, JF; Isaacs, WB

Xu, JF (corresponding author), Johns Hopkins Univ Hosp, 115 Marburg,600 N Wolfe St, Baltimore, MD 21187 USA.; Isaacs, WB (corresponding author), 1001 Univ Pl, Evanston, IL 60201 USA.

EUROPEAN UROLOGY ONCOLOGY, 2020; 3 (2): 224

Abstract

Background: Rare germline mutations in several genes, primarily DNA repair genes, have been proposed to predict worse prognosis of prostate cancer (PC......

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