Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase-MedSci.cn

Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase

Yang, LL; Xu, W; Yan, J; Su, HL; Yuan, C; Li, C; Zhang, X; Yu, ZJ; Yan, YH; Yu, YM; Chen, Q; Wang, ZY; Li, L; Qian, S; Li, GB

Qian, S (reprint author), Xihua Univ, Coll Food & Bioengn, Chengdu 610039, Sichuan, Peoples R China.; Li, GB (reprint author), Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ,Dept Med Chem, Chengdu 610041, Sich

MEDCHEMCOMM, 2019; 10 (1): 164

Abstract

A high-quality X-ray crystal structure reveals the mechanism of compound 1a inhibiting SIRT2 deacetylase and decanoylase. Structure-activity relations......

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Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase

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