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Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine

Shaffer, CL; Dutra, JK; Tseng, WC; Weber, ML; Bogart, LJ; Hales, K; Pang, JC; Volfson, D; Ende, CWA; Green, ME; Buhl, DL

Shaffer, CL (reprint author), Biogen Inc, Res & Dev, External Portfolio Innovat Unit, 225 Binney St, Cambridge, MA 02142 USA.; Buhl, DL (reprint author), Takeda Pharmaceut, Translat Neurosci & Expt Med, 40 Landsdowne St, Cambridge, MA 02139 USA.

NEUROPHARMACOLOGY, 2019; 153 (): 73

Abstract

Ketamine is a rapid-onset antidepressant whose efficacy long outlasts its pharmacokinetics. Multiple studies suggest ketamine's antidepressant effects......

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