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Reversal of siRNA - mediated gene silencing in vivo

Zlatev, I; Castoreno, A; Brown, CR; Qin, J; Waldron, S; Schlegel, MK; Degaonkar, R; Shulga-Morskaya, S; Xu, HL; Gupta, S; Matsuda, S; Akinc, A; Rajeev, KG; Manoharan, M; Maier, MA; Jadhav, V

Jadhav, V (reprint author), Alnylam Pharmaceut, Cambridge, MA 02142 USA.

NATURE BIOTECHNOLOGY, 2018; 36 (6): 509

Abstract

We report rapid, potent reversal of GalNAc-siRNA-mediated RNA interference (RNAi) activity in vivo with short, synthetic, high-affinity oligonucleotid......

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