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Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells

Wu, ZX; Teng, QX; Cai, CY; Wang, JQ; Lei, ZN; Yang, YQ; Fan, YF; Zhang, JY; Li, J; Chen, ZS

Li, J (reprint author), Wuhan Univ, Zhongnan Hosp, Dept Otolaryngol Head & Neck Surg, Wuhan 430071, Hubei, Peoples R China.; Chen, ZS (reprint author), St Johns Univ, Inst Biotechnol, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Queens, NY 11439 USA.

BIOCHEMICAL PHARMACOLOGY, 2019; 166 (): 120

Abstract

Overexpression of ABCB1 transporters plays a crucial role in mediating multidrug resistance (MDR). Therefore, it is important to inhibit ABCB1 activit......

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