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Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling

Chen, T; Yuan, ZQ; Lei, Z; Duan, JL; Xue, JY; Lu, T; Yan, GUA; Zhang, L; Liu, YF; Li, QW; Zhang, YL

Li, QW (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Biliary Pancreat Surg, Shanghai, Peoples R China.;Liu, YF (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Liver Surg, Shanghai 200127, Peoples R China.;Zhang, YL (通讯作者)，Shanghai Jiao Tong Univ, Dept Clin Lab, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China.

THERANOSTICS, 2022; 12 (17): 7450

Abstract

Rationale: Hepatocellular carcinoma (HCC) is one of the most severe cancers worldwide, with few effective targeted therapies for HCC. Lipid metabolic ......

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