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Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases

Chang, A; Xiang, XY; Wang, J; Lee, C; Arakhamia, T; Simjanoska, M; Wang, C; Carlomagno, Y; Zhang, GA; Dhingra, S; Thierry, M; Perneel, J; Heeman, B; Forgrave, LM; DeTure, M; DeMarco, ML; Cook, CN; Rademakers, R; Dickson, DW; Petrucelli, L; Stowell, MHB; Mackenzie, IRA; Fitzpatrick, AWP

Fitzpatrick, AWP (通讯作者),Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10027 USA.;Fitzpatrick, AWP (通讯作者),Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA.;Fitzpatrick, AWP (通讯作者),Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Irving Med Ctr, 630 West 168th St, New York, NY 10032 USA.;Mackenzie, IRA (通讯作者),Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V6T 2B5, Canada.;Stowell, MHB (通讯作者),Univ Colorado, Dept Mol Cellular & Dev Bi

CELL, 2022; 185 (8): 1346

Abstract

Misfolding and aggregation of disease-specific proteins, resulting in the formation of filamentous cellular inclusions, is a hallmark of neurodegenera......

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