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Deterministic evolution and stringent selection during preneoplasia

Karlsson, K; Przybilla, MJ; Kotler, E; Khan, A; Xu, H; Karagyozova, K; Sockell, A; Wong, WH; Liu, K; Mah, A; Lo, YH; Lu, BX; Houlahan, KE; Ma, ZC; Suarez, CJ; Barnes, CP; Kuo, CJ; Curtis, C

Curtis, C (通讯作者),Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;Curtis, C (通讯作者),Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA.;Curtis, C (通讯作者),Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.;Curtis, C (通讯作者),Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA 94305 USA.;Curtis, C (通讯作者),Chan Zuckerberg Biohub San Francisco, San Francisco, CA 94158 USA.

NATURE, 2023; 618 (7964):

Abstract

The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention(1). Here we m......

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