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Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway

Wang, ZJ; Liu, LM; Dai, HL; Si, XJ; Zhang, LY; Li, ED; Yang, Z; Chao, G; Zheng, JX; Ke, Y; Shan, LH; Zhang, QR; Liu, HM

Shan, LH; Zhang, QR; Liu, HM (corresponding author), Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 43 ():

Abstract

In order to find new and highly effective anti-tumor drugs with targeted therapeutic effects, a series of novel 4aminoquinazoline derivatives containi......

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