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Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

Gupta, KK; Donahue, DL; Sandoval-Cooper, MJ; Castellino, FJ; Ploplis, VA

Ploplis, VA (reprint author), Univ Notre Dame, WM Keck Ctr Transgene Res, Notre Dame, IN 46556 USA.; Ploplis, VA (reprint author), Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA.

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fi......

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