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Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

Kwon, YD; Chuang, GY; Zhang, BS; Bailer, RT; Doria-Rose, NA; Gindin, TS; Lin, B; Louder, MK; McKee, K; O'Dell, S; Pegu, A; Schmidt, SD; Asokan, M; Chen, XJ; Choe, M; Georgiev, IS; Jin, V; Pancera, M; Rawi, R; Wang, KY; Chaudhuri, R; Kueltzo, LA; Manc

Mascola, JR; Kwong, PD (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.; Kwong, PD (reprint author), Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA.

CELL REPORTS, 2018; 22 (7): 1798

Abstract

Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, a......

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